Alternate splicing results in multiple transcript variants. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. These pathways regulate that activation of numerous proinflammatory genes. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways.

Full Name MYD88 innate immune signal transduction adaptor provided by HGNC Primary source HGNC:HGNC:7562 See related Ensembl:ENSG00000172936 MIM:602170 AllianceGenome:HGNC:7562 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as WM1 IMD68 MYD88D Summary This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response.

State of survival - plasma core guide